|
T7946 |
AER-271
|
|
Aquaporin
|
|
AER-271 is an inhibitor of aquaporin-4. |
|
T39341 |
FCPR03
|
|
PDE
|
|
FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr... |
|
T23146 |
PHA 568487 free base
|
PHA 568487 |
AChR
|
|
The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia... |
|
T3074 |
CHIR 98024
|
CHIR98014 |
GSK-3
,
S6 Kinase
|
|
CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2. |
|
T0368 |
Cinepazide maleate
|
MD-67350,Vasodistal,Brendil |
Calcium Channel
|
|
Cinepazide maleate (MD-67350), a maleate salt form of cinepazide, is a vasodilator. |
|
T19659 |
Annaosanchun
|
YC6,YC-6,YC 6 |
Others
,
AMPK
|
|
Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS). |
|
T26645 |
Aptiganel
|
CNS 1102,CNS-1102,CNS1102 |
NMDAR
|
|
Aptiganel (CNS-1102) is a non-competitive NMDA antagonist, a peptide that may be used to study acute ischemic stroke. |
|
T77442 |
Glenzocimab
|
ACT017 |
Others
|
|
Glenzocimab (ACT017) is a Fab fragment of a humanized anti-GPVI monoclonal antibody. Glenzocimab demonstrated inhibition of collagen-induced platelet aggregation in an ischemic stroke model. Glenzocimab has been studied ... |
|
T39463 |
Asundexian
|
BAY 2433334,Asundexian,BAY2433334,BAY-2433334 |
Factor Xa
|
|
Asundexian (BAY-2433334) is a potent and orally active inhibitor of the coagulation factor FXIa that directly and reversibly binds to the active site of FXIa, thereby inhibiting its activity.Asundexian has an IC50 of 1 n... |
|
T7355 |
IC87201
|
|
Others
,
iGluR
|
|
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain. |
|
T90611 |
PF-03049423
|
|
|
|
PF-03049423 is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of approximately 0.2 nM for rat and human thrombomodulin. PF-03049423 can be used in studies about acute ischemic stroke studies. |
|
T3527 |
TRC051384
|
TRC 051384 |
HSP
|
|
TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated ... |
|
T21757 |
BRL 52537 hydrochloride
|
|
Opioid Receptor
|
|
BRL 52537 hydrochloride is a selective and specific KOR agonist which has been implicated in neuroprotection from ischemic neuronal injury[1]. It is used for research into potential treatments for stroke and heart attack... |
|
T78141 |
LFHP-1c
|
|
Phospholipase
|
|
LFHP-1c, a neuroprotective PGAM5 inhibitor, demonstrates efficacy in preserving blood-brain barrier integrity following ischemic stroke. It achieves this by binding to endothelial PGAM5, thereby inhibiting its phosphatas... |
|
T13112 |
Tat-NR2B9c
|
Tat-NR2Bct,NA-1 |
NO Synthase
,
iGluR
|
|
Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi... |
|
T31206 |
Darexaban
|
YM 150,Darexaban, Tanexaban,YM150 |
Factor Xa
|
|
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati... |
|
T70540 |
Pinokalant
|
LOE-908 |
SARS-CoV
,
TRP/TRPV Channel
|
|
Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem... |
|
T34086 |
Platonin
|
NK 19 |
|
|
Platonin is a therapeutic immunomodulating medicine and a possible medicine against ischemic stroke. |
|
T31978 |
GM-608
|
GM-606,GM-607,GM-604,GM-603,GM-605,GM-602 |
|
|
GM-604(alirinetide) is a potential treatment for amyotrophic lateral sclerosis and ischemic stroke. |
|
T28438 |
2-(1-hydroxypentyl)benzoic Acid
|
dl-PHPB |
|
|
Potassium-Hydroxypentyl Benzoate is a drug potentially for the treatment of acute ischemic stroke (AIS) |
|
T27309 |
Fenazinel Dihydrochloride
|
SIPI5052,SIPI 5052,SIPI-5052 |
|
|
Fenazinel Dihydrochloride, a N-methyl-D-aspartate (NMDA) receptor antagonist, is used potentially for the treatment of ischemic stroke. |
|
T17287 |
ZD-1611
|
|
Others
|
|
ZD-1611 is an effective and selective ETA receptor antagonist. It is used for the research of ischemic stroke. |
|
T71969 |
Remacemide
|
|
|
|
Remacemide is a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke, epilepsy, Huntington's disease, and Parkinson's disease. |
|
T73452 |
MRS4596
|
|
|
|
MRS4596, a potent and selective antagonist of the P2X4 receptor, exhibits an IC50 of 1.38 μM for the human P2X4 receptor. This compound demonstrates both neuroprotective and neuro-rehabilitative effects in ischemic strok... |
|
T81581 |
OY-201
|
|
|
|
OY-201 is a promising anti-ischemic stroke agent capable of crossing the blood-brain barrier (BBB). It demonstrates significant safety and neuroprotective activity in in vitro and in vivo models [1]. |
|
T73453 |
MRS4719
|
|
|
|
MRS4719, a potent P2X4 receptor antagonist, exhibits a half-maximal inhibitory concentration (IC50) of 0.503 μM for the human P2X4 receptor. Demonstrating both neuroprotective and neuro-rehabilitative effects, it can dec... |
|
T81899 |
LY836
|
|
iGluR
|
|
LY836 is an orally active, neuroprotective compound that effectively inhibits the PSD95-nNOS association in cortical neurons. It has potential applications in the study of ischemic stroke [1]. |
|
T60732 |
A2A/A1 AR antagonist-1
|
|
|
|
A2A/A1 AR antagonist-1 (compound 1a) has the potential for ischemic stroke research which is potent A 2A /A 1 AR dual antagonist with Ki s of 5.58 and 24.2 nM, respectively [1]. |
|
T80024 |
Cationic Bovine Serum Albumin
|
cBSA, chemically modified cationic bovine serum albumin |
|
|
Cationic Bovine Serum Albumin, a protein of 583 amino acids with three homologous alpha structural domains, exhibits significant neuroprotective effects against ischemic stroke when used in conjunction with Tanshinone II... |
|
T80154 |
TAT-CIRP
|
|
|
|
TAT-CIRP, a trans-activating (Tat) cold-inducible RNA-binding protein-derived peptide, functions as an inhibitor of myeloid differentiation protein 2 (MD2). It has demonstrated significant neuroprotective effects against... |
|
T73989 |
Tirilazad
|
|
|
|
Tirilazad, a nonglucocorticoid 21-aminosteroid, serves to inhibit lipid peroxidation. It mitigates the effects of trauma-induced brain or spinal cord injury, as well as damage resulting from stroke, ischemia, and reperfu... |
|
T37669 |
CAY10498
|
|
|
|
The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. The four AR subtypes have been implicated in several areas of therapeutic interest such as stroke and other ischemic conditio... |
|
T80419 |
TAT-NEP1-40 TFA
|
|
Apoptosis
|
|
TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth. Additionally, it enhances neurological outcomes post-ischemia by... |
|
T83695 |
MOG Peptide (human, bovine) acetate
|
Myelin Oligodendrocyte Glycoprotein Peptide |
|
|
Myelin oligodendrocyte glycoprotein (MOG) peptide, a truncated form of MOG located on the extracellular myelin sheath surface, interacts with antigen serotype HLA-DR2 to mitigate effects of ischemic stroke induced by mid... |
|
T36570 |
KUS121
|
|
|
|
KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, ... |
